Cambridge University aims for autumn trials of coronavirus vaccine after UK funding

first_img“Ultimately we aim to make a vaccine that will not only protect from SARS-CoV-2, but also other related coronaviruses that may spill over from animals to humans.”No vaccine against the SARS-CoV-2 coronavirus which causes COVID-19 has yet been proven clinically effective, though 30 that use a range of technologies are in human trials already.The Cambridge candidate, DIOS-CoVax2, is DNA based. Computer-generated antigen structures are encoded by synthetic genes, which can then re-programme the body’s immune system to produce antibodies against the coronavirus.This DNA vector method has been shown to be safe and effective at stimulating an immune response in other pathogens in early stage trials, the university said. The University of Cambridge is aiming to start clinical trials of its possible coronavirus vaccine in the autumn after it received 1.9 million pounds ($2.5 million) in funding from the British government, the university said on Wednesday.The scientists behind the vaccine said their approach, which uses genetic sequences of all known coronaviruses to hone the immune response, could help avoid the adverse effects of a hyper-inflammatory immune response.”We’re looking for chinks in its armor, crucial pieces of the virus that we can use to construct the vaccine to direct the immune response in the right direction,” Jonathan Heeney, head of the Laboratory of Viral Zoonotics at the University of Cambridge, said. Topics :center_img Although it is operating at a later timetable than some other vaccine candidates, the DIOS-CoVax2 shot would not need to be stored at cold temperatures and could be delivered without needles, possibly making the widespread distribution of the vaccine easier.”This could be a major breakthrough in being able to give a future vaccine to huge numbers of people across the world,” said Saul Faust, Director of the NIHR Southampton Clinical Research Facility.last_img read more

Blues seal Van Ginkel deal

first_img The 20-year-old moves from Eredivisie side Vitesse Arnhem for an undisclosed fee and has penned a five-year deal at Stamford Bridge. Van Ginkel came through the youth system at Vitesse and made his international debut as a substitute in a goalless draw against Germany in November. Chelsea have completed the signing of Holland midfielder Marco van Ginkel, the club have announced. Press Associationlast_img

Field narrows as Giants move on to second round of manager interviews

first_imgSAN FRANCISCO — The San Francisco Giants are moving on to the next phase of their search to find Bruce Bochy’s replacement.President of baseball operations Farhan Zaidi has begun notifying candidates of whether or not they’ll receive a second interview for the chance to become the Giants’ next manager. Former Phillies manager Gabe Kapler and current Houston Astros bench coach Joe Espada are reportedly among those who will remain involved in the process.According to Florida-based radio host …last_img

Dave Sittler and Bill Young

first_imgDave Sittler and Bill Young have a really interesting conversation that I’m betting all my January paychecks neither knew was being picked up by the microphone. Take a look below with some comments after the jump. – I like how Sittler makes it a point in the first two seconds to let Young know that he has his tape recorder turned off but neither of them checks the mic. That’s pretty funny.– Sittler calls John Blake a slapdi** after Bill Young says “it wasn’t fun” about being at OU under Blake in 1996-1997 then Sittler goes on to claim that Donnie Duncan (OU’s athletic director at the time) told him that the only reason he gave John Blake the head coaching job for OU was because he was black and they were worried that Bob Simmons had an advantage in recruiting. That’s quite a 20-second exchange, no?! I mean, WOW!– Love when Young says “…and three years later we forgot how to coach.”– What does Young mean when he says “I would almost bet you 100% that some of these schools…maybe even the one down the street [came after Gundy]”? What are they going to do, fire Stoops?Update: as a few of you have pointed out, Young was referencing Arizona State as “the school down the street”, not OU. Makes sense now.– The long-range shot of the two talking at the 3:40 mark really shows you that they have no clue they’re on the mic.– “I just hope I’m going to be back.” Assuming he’s kidding, because If he’s not, that’s a travesty. He’s done a great job with the defense this season and seems like a great fit for the position. Also, he’s the only guy on the staff too old to be considered for a head job!If you’re looking for the comments section, it has moved to our forum, The Chamber. You can go there to comment and holler about these articles, specifically in these threads. You can register for a free account right here and will need one to comment.If you’re wondering why we decided to do this, we wrote about that here. Thank you and cheers!last_img read more

Suspect accused of killing Phoenix in fatal Point Loma shooting arrested

first_img Posted: October 25, 2018 KUSI Newsroom, SAN DIEGO (KUSI) — Authorities Thursday publicly identified a 20-year old woman fatally shot two weeks ago in front of a Point Loma Heights strip mall, allegedly by her boyfriend, who has remained at large since.Patrol officers responding to reports of gunfire found Octavia Williams of Phoenix, Arizona, mortally wounded in a parking lot in the 4000 block of West Point Loma Boulevard shortly after 11:30 p.m. Oct. 9, according to San Diego police.Medics took Williams to a hospital, where she was pronounced dead.Homicide investigators believe that the victim’s boyfriend, 41-year- old Joe Bennette Conway, shot her over some type of disagreement before fleeing, Lt. Anthony Dupree said.Investigators have few leads on the whereabouts of Conway, who, according to police, may be driving a red four-door Chevrolet Cavalier with Arizona license plates.A warrant was issued for Conway’s arrest for murder. On October 30, 2018, Conway was located and arrested in Tempe Arizona with the help of the Phoenix Police Department. Conway isbeing held pending extradition for the murder of Williams. Suspect accused of killing Phoenix in fatal Point Loma shooting arrested October 25, 2018center_img Updated: 7:51 AM KUSI Newsroom Categories: Local San Diego News FacebookTwitterlast_img read more