Nucleic Acid Therapy Accelerator: ‘NATA’ (£30 million) – brand new therapies and technologies directly targeting genetic mutations could be rolled out to treat diseases including cancer, Huntingdon’s, Parkinson’s and arthritis The Advanced Pain Discovery Platform (£12 million) – deepening our understanding of pain, this will reveal new treatment approaches and address a wide spectrum of chronic and debilitating conditions including arthritis. Versus Arthritis will contribute an additional £12 million over 3 years UK Centre of Evidence Implementation in Adult Social Care (£7.5 million) – using high quality research, this project will lead to improvements in the delivery of social care across the UK; implementing innovations with the potential to allow more people to receive care from the comfort of their own home Tackling Multimorbidity at scale (£20 million, of which the National Institute of Health Research (NIHR) is contributing £10 million) – this research into multimorbidity – when someone is suffering 2 or more long-term health conditions – will propel forward drug development, allow for earlier diagnosis and reduce progression to more severe illness and disability Minister for Innovation Nicola Blackwood said: People across the country could lead healthier and longer lives following significant government investment in new research to improve treatment, diagnosis and care options for devastating diseases including cancer.The government has today (9 September) unveiled details of how it will help thousands of people across the country living with debilitating, painful and/or sometimes life-threatening diseases by investing £133 million in life-changing treatments for arthritis and cancer and for pioneering gene-based therapies for diseases including dementia and Parkinson’s.Faster, more accurate diagnosis, and earlier interventions will be boosted by £50 million to be pumped into NHS diagnostic services and support the work of existing Centres of Excellence in digital pathology and imaging with artificial intelligence. The centres – based in Leeds, Oxford, Coventry and London – will be able to partner with more NHS Trusts and further develop cutting edge products using digital systems and artificial intelligence that could ultimately save lives.Adult social care will also receive a new cash injection of £7.5 million to use research to improve care delivery for some of the most vulnerable people in our society and £14 million for bioscience projects and technologies across the UK that could, for example, treat osteoarthritis and develop new vaccines.Business Secretary Andrea Leadsom said: Supporting people to live long, healthy and independent lives is a fundamental value of our society and, as our population ages, one of the biggest challenges we face. This £133 million investment will tackle important chronic diseases and also create a national centre of evidence for implementing the best evidence to provide adult social care. The UK is a global powerhouse in health research and innovation. The investments announced today will cement this, and help to further deliver on the NHS’s international leadership on applying artificial intelligence to complex health problems. Today’s announcement is good for patients, good for staff and good for researchers. A further £69.5 million of the total investment through UK Research and Innovation (UKRI) will help fund 4 British projects: Notes to editorsThe Centres of Excellence fundingThe Centres of Excellence in digital pathology and imaging with AI were originally established in 2018 by UKRI. They bring together the NHS, industry, and academia who work together to develop products using advances in digital technology to improve early diagnosis of disease, including cancer by detecting abnormalities. The programme, managed by UKRI, will allocate the £50 million via a competition run between the 4 centres. The bids must demonstrate how funding will be used by the centres to invest in digital infrastructure and equipment in partner NHS Trusts, and digitally link these trusts to the centres. This will expand the geographic coverage of the NHS trusts who are able to work with the centres.Strategic Priorities FundThe Strategic Priorities Fund (SPF) supports high quality research and development priorities. This is the second wave of funding. The SPF Wave 2 total programme funding allocation is £496.8 million.More details about the funding projectsNucleic Acid Therapy Accelerator: ‘NATA’ (MRC) Supported by MRC with DHSC, BEIS, Harwell Research Campus and Oxford University.Funding requested: £30 million over 4 years. Location(s): The intention is to establish the NATA core infrastructure hub at Harwell Research Campus (Oxford). However, the challenges will be open to higher education institutions (HEIs), Institutes, public sector research establishments (PSREs) and/or businesses across the UK. Nucleic acid therapies are precision genomic medicines.The Advanced Pain Discovery Platform: Mapping the complexity of chronic pain (MRC) MRC and Versus Arthritis with BBSRC and Innovate UK.Funding requested: £12 million over 3 years. Versus Arthritis will contribute an additional £12 million over 3 years. Location(s): The intention is to build a national capability through calls which are open to HEIs, Institutes, PSREs and/or businesses across the UK.UK Centre of Evidence Implementation in Adult Social Care (ESRC) ESRC and The Health Foundation. Funding requested: £7.5 million over 8 years. This is co-funded by an additional £7.5 million by the Health Foundation, who are working in partnership with Economic and Social Research Council.Location(s): This is an open competition to deliver a nationally distributed and locally embedded centre through a call which is open to HEIs, independent research organisations and PSREs.Tackling Multimorbidity at scale: Unpicking disease clustering biological pathways and trajectories (MRC) MRC with DHSC and NIHR. Funding requested: £20 million over 4 years. UK Research and Innovation Chief Executive, Professor Sir Mark Walport, said: Health Secretary Matt Hancock said: Chronic and painful illnesses like arthritis and Parkinson’s are dreadful and prevent people from living a full life. Curing these kinds of debilitating illnesses is one of the great challenges we face globally, and today’s commitment will play a vital role in ensuring that our scientists and thinkers have the tools they need to find new treatments that will support people to lead longer, healthier lives. We’ve got to bring NHS technology into the 21st century. I’ve seen for myself how better technology and diagnosis can save clinicians’ time so they can concentrate on care. The NHS is now spearheading world-leading technologies that can transform and save lives through new treatments, diagnosis techniques and care. I’m determined that the benefits of these advances will improve the lives of thousands of patients whose conditions have long been considered life-limiting. Combined with this new funding, none of this would be possible without the long-term plan, backed by an extra £33.9 billion a year for the NHS. government investing £133 million in healthcare innovation including gene-based therapies and artificial intelligence funding will unlock new treatments that allow people to lead healthier and longer lives This is co-funded by NIHR, who are providing half of the £20 million and are working in partnership with the Medical Research Council.Location(s): The intention is to build a national capability through calls which are open to HEIs, independent research organisations and PSREs across the UK.BackgroundThe £14 million has been awarded to cutting-edge bioscience projects across the UK by the Biotechnology and Biological Science Research Council (BBSRC).The government’s Ageing Society Grand Challenge aims to ensure that people across the UK enjoy an extra 5 years of healthy and independent living by 2035, whilst narrowing the gap between the experience of the richest and the poorest.With 1 in 7 of us expected to be over 75 by 2040, today’s investment announcement will be an essential step in developing the products and services to support the UK’s ageing society by keeping them healthy, active and independent for as long as possible. Investing in innovation to promote longer, healthier lives is the aim of the government’s Ageing Society Grand Challenge.This cash boost is the latest move by the government to address the needs of our elderly citizens and meet its goal of helping everyone to enjoy 5 extra healthy and independent years by 2035. Earlier this year, a £300 million competitive fund was announced to address innovations and new technologies to helps people live in their homes longer, tackle loneliness and increase independence.
Press Association Since Steve Clarke left in December 2013 they have battled relegation but host QPR on Saturday looking to move 11 points clear of the bottom three. And Pulis, who replaced Alan Irvine in January, is eager to finish the job and revive the Baggies. “It has gone a little bit off the rails in the last two or three years,” he said. “I don’t think anyone can argue about that, it is now just about trying to get it back on track. “We will talk about it (the summer transfer market) once we have achieved our goals – which is to stay up. We are still points away from that. “Once that is achieved we will sit down and talk to the chairman, “It is a good football club, everything is in place.” Victory over Rangers would put the Baggies 14 points clear of the second-bottom visitors but Pulis is taking nothing for granted. “Every game we play is a chance to pick up points in the Premier League,” he said. “We will respect QPR, they have the tools to win a game in this division.” The Baggies head coach has shelved any thoughts of summer safety until Albion have clinched their Barclays Premier League future. Albion struggled last term, beating the drop by three points, and Pulis is their third manager in the last 12 months. Boss Tony Pulis is ready to rebuild West Brom after they went “off the rails”.
cormac foster How It’s Doing: So far, it seems to be still growing. Getaround has signed up thousands of cars, and it’s hiring for aggressive expansions into new markets. The startup’s most recent venture is Getaway, a long-term rental service for drivers who need a car for a week or longer. But over all, the car-sharing market has a long way to go before becoming mainstream. New York, 2010: QwikiWhat It Is: Qwiki is a slick, simple, online application that lets users create video presentations in their browser. The interface is extremely simple, and and even a total noob can throw together a slick-looking video in less than five minutes. How OKR’s Completely Transformed Our Culture Tags:#start#Venture Funding With TechCrunch Disrupt SF 2012 in full swing this week, it’s only a matter of days before a new winner is crowned. We decided to check in with previous Disrupt winners to see how they’ve fared since their victories – and try to determine how it means to ace a high-profile startup contest.Startup contests like TechCrunch Disrupt can generate a lot of hype and interest, but does that translate into any lasting benefit for the startups involved? Sure, winning brings monetary benefits – TechCrunch Disrupt offers $50,000 – which never hurts, but does participating really help a startup succeed? And does winning a key contest really predict eventual success? To find out, we caught up with the winners of the four most Disrupt events: Related Posts How It’s Doing: Most avatar-based chat environments have been notoriously anonymous, quickly degrading from social discovery to Leisure Suit Larry. Shaker removes the anonymity by tying profiles to your Facebook account, helping users to meet others with common interests snd form real relationships. Promoters (at this point, mostly bands) sponsor rooms, and Shaker works its magic on the back end to segment the rooms so you’ll actually bump into people with shared interests beyond the band.For now Shaker remains a bit of a ghost town. As of September 10, there were only two events on the calendar: a Foo Fighters Tribute party with 226 RSVPs, and a “Hangout” the following Sunday with 37. Still, Live Nation has signed on as a promotional partner, which could help Shaker attract the users it needs to really take off. New York, 2011: GetaroundWhat It Is: Getaround is AirBnB for car rentals. Owners can list their cars during downtime, allowing drivers to rent them by the hour. Drivers can place up to five requests, and the first response wins the business. One price covers rental cost, background checks and insurance. Owners get a monthly payment for their car, drivers get to drive whatever they want while saving money, and Getaround takes a cut from the middle without having to maintain its own inventory. The concept is a win-win-win. How to Get Started in China and Have Success How It’s Doing: Qwiki works great for last-minute school presentations or fashion retrospectives, but as others have pointed out, it has yet to become the transformative application its founder promised. To date, Qwiki hasn’t disrupted much of anything, but recent ties to more mainstream media outlets could help change that.Even the hottest startup needs a little time to change the world – or make a billion dollars – so it’s a little early to pass final judgment. But so far, at least, the four most recent Disrupt winners are all still in business – and not every startup can say the same.At the same time, though, while some have gotten funding, none has come close to changing the world or a transformative financial event for founders and investors. And plenty of other startups – ones who didn’t win startup contests – or doing even better. New York, 2012: ÜberConferenceWhat It Is: Audio conference calls aren’t going away, so Firespotter Labs’ ÜberConference made them less sucky. By removing login annoyances (“Can you text me that code? I’m on my cell!”), adding visual controls and giving you something productive to do with your mouse and keyboard while sitting on hours of endless calls, ÜberConference actually makes audio calls cool again. What Nobody Teaches You About Getting Your Star… China and America want the AI Prize Title: Who … How It’s Doing: Uberconference is killing it. Just a month after taking home first prize at Disrupt, Firespotter won $15 million from Andreessen Horowitz and Google Ventures. The company is hiring for several open positions, most of them in engineering. iOS, Android and paid versions of the service are due soon, and UberConfernce can monetize its already-solid feature set, prospects look good. San Francisco, 2011: ShakerWhat It Is: Shaker’s founders are betting that users will want to hang out in virtual spaces (starting with a bar called Club 53), represented by avatars. If this strikes you as a little like Second Life, you’re not alone, but the folks at TechCrunch and $18 million in venture funding believed Shaker offers something more than just another chat room.
Polling passed off peacefully in six Lok Sabha and 42 Assembly constituencies of Odisha in the third phase of simultaneous elections on Tuesday.An average of 61% voting was recorded till 5 p.m., and it was likely to increase since voting was in progress, according to the Chief Electoral Officer, Odisha. The Lok Sabha seats where polling was conducted during the day are Puri, Bhubaneswar, Cuttack, Dhenkanal, Sambalpur and Keonjhar. The 42 Assembly segments came under these six Parliamentary constituencies.EVMs malfunctioningReports of malfunctioning of EVMs were received from some booths in the morning hours, but polling was resumed after replacing those machines. Polling was postponed in a booth under Sambalpur following error and wrong pairing of VVPAT.In another incident, a polling official passed away while on duty in Dhenkanal district. The official, Nabakishore Nayak, who collapsed inside the booth, was declared dead by doctors at Kamakhyanagar hospital.Chief Minister and Biju Janata Dal president Naveen Patnaik was among the prominent leaders to cast their votes in the morning hours. After casting his vote, Mr. Patnaik exuded confidence that the BJD would perform well in the elections in the State.The prominent candidates who were in the fray for Tuesday’s elections include former IAS officer Aparajita Sarangi, former Mumbai Police Commissioner Arup Patnaik, former Director General of Police Prakash Mishra and BJP national spokesperson Sambit Patra.4th phase on April 29 Polling is already over in nine Lok Sabha and 63 Assembly constituencies in Odisha in the previous two phases – April 11 and 18. The fourth and last phase polling in the remaining six Lok Sabha and 42 Assembly constituencies, for which campaigning is still going on, is scheduled to be held on April 29.On the other hand, Mr. Patnaik campaigned for party nominees in areas under the Balasore, Bhadrak, Jajpur and Kendrapara Lok Sabha constituencies later in the day. Prime Minister Narendra Modi also addressed two public meetings at Balasore and Kendrapara during the day.
Commonwealth Games organising committee (OC) chairman Suresh Kalmadi today claimed that the standard of training facilities available at the Delhi Games Village is best in the world.”The standard of training facilities that are available here are not available anywhere else in the world. This is one of the best Games Villages that anyone has seen,” Kalmadi said on the occasion of the soft launch of the Commonwealth Games Village here today.”All the facilities in the Village are top class and I am sure the athletes are going to love it. “The training areas comprising of the swimming pool, athletic track, gymnasium, weightlifting and wrestling areas are simply wonderful. In a Games Village, generally, all these facilities are not available at such a large scale,” he added.Putting to rest all rumours about the readiness of the Games Village, Kalmadi, himself led the media contingent to the various parts of the Games Village.”The whole village is ready. The international, the training centres and the accommodations are all in place. The Games Village will open from September 23 and we will have a lot of athletes coming in on September 23, 24 and 25 and they will continue to come till October 2,” said Kalmadi.He also stressed that it is not only their stay at the Games Village that the athletes are going to enjoy but also the event as a whole. “Every evening we are going to have entertainment programmes for the athletes.”Also for the first time, the athletes would be watching the opening ceremony of the CWG. Usually, after the march past they go outside. But here they would come back and sit inside the stadium and watch the cultural programmes, which is going to show 500 years of Indian culture.advertisement”By the time they will go back they will be like a family. They will come as a friend and go back as family. They will enjoy themselves,” said Kalmadi.Addressing the security concerns during the sporting extravaganza that is going to take place from October 3-14, the OC Chairman said, “We just had a security meeting and all issues of security have been sorted out. The Delhi Police have done a great job.”In fact, some of the top officials of Delhi Police have previous experiences of how to run the security during the Games as they have been to Olympics and Commonwealth Games in other countries. The security in the Games Village is of top priority and I am very happy with the arrangement.”All 71 countries are coming. Nobody is afraid. Everyone’s coming. The CWG Association had comprised a team, who used to visit India after every two months. So everyone’s happy about the security,” Kalmadi said.Speaking on the utilisation of the space in the Village, which is spread over 158.4 acres of land, after the Games are over, Kalmadi said it would be a challenge. “There have been a lot of discussion on how to utilise large portions of land after the Games are over. Usually, after such big events there is always a question of how to use these structures and that is a challenge.”The DDA has a lot of sports background. They have opened lot of clubs in the city. After the Asian Games, they opened clubs for the public use and I am sure in this case also they will use it for the public,” he said.Kalmadi also rubbished reports that Dengue will pose a threat to the athletes as the Games Village is still surrounded by a lot of flood water from Yamuna and said there is no need to panic.”Central government, State govt and the MCD are on war footing as far as Dengue is concerned. Lot of Insecticides have been put into place. Lot of fogging is also being done. “The fogging of the Games Village is going to take place from tomorrow. So, we are taking all steps to have safe and healthy Games. There is no cause for alarm at all.
TagsTransfersAbout the authorPaul VegasShare the loveHave your say Kante: What Chelsea players think of Pulisicby Paul Vegas10 months agoSend to a friendShare the loveChelsea midfielder N’Golo Kante has welcomed their swoop for Borussia Dortmund winger Christian Pulisic.On Wednesday morning it was announced that the 20-year-old will be moving to west London this summer in a £58million move from Borussia Dortmund.Having watched Pulisic’s impact from afar, Kante can’t wait to see it close up next season.”We know he’s a good player,” he told the Daily Mail following Chelsea’s 0-0 draw with Southampton in the Premier League on Wednesday night.”He’s doing well for Dortmund and we are glad to welcome him to Chelsea.”
Wolves boss Nuno: No underestimating Watfordby Paul Vegasa month agoSend to a friendShare the loveWolves boss Nuno says there’ll be no underestimating Watford this weekend.The Hornets go into the game having been thrashed 8-0 by Manchester City.Nuno said, “Quique (Flores) is a fantastic manager and he has done very good jobs around the world.“Anything can happen. Last week and this week are different. We must analyse the games they’ve played and take important information to pass onto the players.“I have had (a big defeat) in football, good moments and bad moments. For us it’s also a moment to try and raise our standards.” About the authorPaul VegasShare the loveHave your say
Braxton Miller One-HandedUpdate: Miller posted a video on his own account from a different angle. Earlier: Any concerns over Braxton Miller’s hands following his move to wide receiver could likely be alleviated by watching this video from the Ohio State football Instagram account. In the clip, Miller fields a ball launched from a JUGS machine while holding five other footballs. Ohio State deleted the post for some reason, but For The Win put it on YouTube. Yea, looks like he’s going to adjust just fine. [ For The Win ]
Any version of “Bad Lip Reading” (video of people talking with their voices dubbed over) is usually ridiculously funny. This rendition, produced by Notre Dame football, is no different.Quarterback Malik Zaire and defensive lineman Jay Hayes are in the studio providing the voice-over work. They are both really, really funny. The footage from the video is from last season. If you’re an Irish fan, you should definitely watch this, but if you’re just a fan of laughing a lot, check it out as well. A little something to brighten up your Monday…Courtesy of Malik Zaire and Jay Hayes.https://t.co/iMLte4Dal6— Notre Dame Football (@NDFootball) March 21, 2016